Description
Human Angiogenin / RNASE5 Protein, His Tag | ANN-H5149-1mg| Gentaur Distribution US, UK & Europe
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Source: Human Angiogenin, His Tag (ANN-H5149) is expressed from E. coli cells. It contains AA Gln 25 - Pro 147 (Accession # P03950-1).
Format: Powder.
Tag: N-10×His.
Expression System: E. coli.
Expression Region: Gln 25 - Pro 147.
Conjugate: Unconjugated.
Molecular Weight: 16.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 16.0 kDa. The protein migrates as 12 kDa and 17-18 kDa under reducing (R) condition (SDS-PAGE).
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
