Human Alpha-Synuclein Protein, Tag Free (MALS verified) | ALN-H5214-200ug

Human Alpha-Synuclein Protein, Tag Free (MALS verified) | ALN-H5214-200ug| Gentaur Distribution US, UK & Europe

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Source: Human Alpha-Synuclein, Tag Free (ALN-H5214) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).

Format: Liquid.

Tag: Native.

Expression System: E. coli.

Expression Region: Met 1 - Ala 140.

Conjugate: Unconjugated.

Molecular Weight: 14.5 kDa.

Characteristics: This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 15-16 kDa under reducing (R) condition (SDS-PAGE).

Purity: 90%.

Buffer: 50 mM HEPES, 100 mM NaCl, pH7.5.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice