Human Alpha-Synuclein Protein, Fc Tag (MALS verified) | ALN-H5253-200ug

Human Alpha-Synuclein Protein, Fc Tag (MALS verified) | ALN-H5253-200ug| Gentaur Distribution US, UK & Europe

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Source: Human Alpha-Synuclein, Fc Tag (ALN-H5253) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 140 (Accession # P37840-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Met 1 - Ala 140.

Conjugate: Unconjugated.

Molecular Weight: 40.9 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.9 kDa. The protein migrates as 47-52 kDa and 53-56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT