Description
Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag (ThT active) | ALN-H51H4-1mg| Gentaur Distribution US, UK & Europe
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Source: Human Alpha-Synuclein Pre-formed Fibrils, His Tag (ALN-H51H4) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
Format: Liquid.
Tag: C-10×His.
Expression System: E. coli.
Expression Region: Met 1 - Ala 140.
Conjugate: Unconjugated.
Molecular Weight: 16.3 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
