Description
Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified) | ALN-H5117-1mg| Gentaur Distribution US, UK & Europe
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Source: Human Alpha-Synuclein (E46K), Tag Free (ALN-H5117) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (E46K) ).
Format: Liquid.
Tag: Native.
Expression System: E. coli.
Expression Region: Met 1 - Ala 140.
Conjugate: Unconjugated.
Molecular Weight: 14.5 kDa.
Characteristics: This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).
Purity: 95%.
Buffer: 50mM HEPES, 100mM NaCl, pH8.0.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
