Human Alpha-Synuclein (A53T) Protein, His Tag (MALS verified) | ALN-H51H5-200ug

Human Alpha-Synuclein (A53T) Protein, His Tag (MALS verified) | ALN-H51H5-200ug| Gentaur Distribution US, UK & Europe

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Source: Human Alpha-Synuclein (A53T), His Tag (ALN-H51H5) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (A53T) ).

Format: Powder.

Tag: C-10×His.

Expression System: E. coli.

Expression Region: Met 1 - Ala 140.

Conjugate: Unconjugated.

Molecular Weight: 16.4 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 18-19 kDa under reducing (R) condition (SDS-PAGE).

Purity: 90%.

Buffer: 100 mM NaAC, pH7.0.

Storage Conditions: -20℃.

Shipping Conditions: RT