Human ALK-1 / ACVRL1 Protein, His Tag | AL1-H5228-1mg

Human ALK-1 / ACVRL1 Protein, His Tag | AL1-H5228-1mg| Gentaur Distribution US, UK & Europe

Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.

Source: Human ALK-1, His Tag (AL1-H5228) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Gln 118 (Accession # P37023).

Format: Powder.

Tag: C-6×His.

Expression System: HEK293.

Expression Region: Asp 22 - Gln 118.

Conjugate: Unconjugated.

Molecular Weight: 12.6 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.6 kDa. The protein migrates as 23-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT