Human Activin RIIA / ACVR2A Protein, Fc Tag | ACA-H5269-200ug

Human Activin RIIA / ACVR2A Protein, Fc Tag | ACA-H5269-200ug| Gentaur Distribution US, UK & Europe

Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2, which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.

Source: Human ACVR2A, Fc Tag (ACA-H5269) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 135 (Accession # P27037-1).

Format: Powder.

Tag: N-Fc.

Expression System: HEK293.

Expression Region: Ala 20 - Pro 135.

Conjugate: Unconjugated.

Molecular Weight: 39.9 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 39.9 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT