Description
Human Activin RIB / ACVR1B Protein, His Tag | ACB-H52H4-1mg| Gentaur Distribution US, UK & Europe
Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.
Source: Human Activin RIB, His Tag (ACB-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Glu 126 (Accession # P36896-1).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Ser 24 - Glu 126.
Conjugate: Unconjugated.
Molecular Weight: 13.3 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.3 kDa. The protein migrates as 16-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
