Description
HSPA8 Antibody | R30914 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC-P
Buffer: N/A
Limitation: This HSPA8 antibody is available for research use only.
Purity: Antigen affinity
Description: Heat shock 70kDa protein 8, also known as HSC70, HSC71, and HSP73 is a heat shock protein that in humans is encoded by the HSPA8 gene. The gene contains 9 exons and spans 5 kb. The deduced protein has 646 amino acids and a predicted molecular mass of 70,899 Da. The HSPA8 is mapped on 11q24.1. HSPA8 plays an important role in cells by transiently associating with nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Rapid decay involves AU-rich binding protein AUF1, which complexes with heat-shock proteins HSPA8 and HSP70, translation initiation factor EIF4G, and poly(A)-binding protein. In the absence of IL3, HSPA8 formed a complex with HSP40 and Hip, and this complex, in association with Eif4g and Pabp, formed a high-stability complex with Bim mRNA that protected it from ribonucleases.
Immunogen: An amino acid sequence from the C-terminus of human Heat shock 70kDa protein 8 (NDEDKQKILDKCNEIINWLD) was used as the immunogen for this HSPA8 antibody.
Storage: After reconstitution, the HSPA8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
