Description
HSPA5 Antibody / GRP78 / BiP | F54813-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Zebrafish
Application: IF, WB, IHC-P
Buffer: N/A
Limitation: This HSPA5 antibody is available for research use only.
Purity: Antigen affinity purified
Description: When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.
Immunogen: A portion of amino acids 261-289 from the human protein was used as the immunogen for the HSPA5 antibody.
Storage: Aliquot the HSPA5 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
