Description
HSP90β, His-tag | 50292 | Gentaur US, UK & Europe Disrtribition
Category: Heat Shock Protein/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with > 100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic proteins. Inhibition of Hsp90beta function has been shown to play a role in tumorigenesis and disease progression.
Description: Human Heat Shock Protein 90β (GenBank Accession No. AY359878), full length with C-terminal His-tag, MW = 83 kDa, expressed in an E. coli expression system.
Product Type: Protein
Shippement Condition: -80°C
