HSD17B2 Antibody | R30683

HSD17B2 Antibody | R30683 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC-P, IHC-F

Buffer: N/A

Limitation: This HSD17B2 antibody is available for research use only.

Purity: Antigen affinity

Description: HSD17B2(17-beta-hydroxysteroid dehydrogenase II), also called 17-beta-HSD II, is an enzyme with 387 amino acids, a predicted molecular weight of 42,782D, and associate with the membranes of the endoplasmic reticulum. The type 2 enzyme is capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43%) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And it activity distinguishing between disease-free and diseased endometria. It efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

Immunogen: Amino acids 373-387 (MPRALRMPNYKKKAT-human) were used as the immunogen for this HSD17B2 antibody.

Storage: After reconstitution, the HSD17B2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.