Description
HSD11B2 Polyclonal Antibody | E-AB-67942 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Rat
Host: Rabbit
Isotype: IgG
Application: WB, IHC
Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction
Background: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant fusion protein of human HSD11B2 (NP_000187.3).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification: Affinity purification
Dilution: WB 1:200-1:1000 IHC 1:50-1:100
Conjugation: Unconjugated
Calculated Molecular Weight: 44 kDa
Observed Molecular Weight: 44 kDa
Clonality: N/A
