Description
HPV-16 E1/E4 Antibody | V8338-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: HPV16 E1/E4
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Type 16 of Human Papilloma Virus (HPV-16).
Application: IHC-P
Buffer: N/A
Limitation: This HPV16 E1/E4 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.
Immunogen: A recombinant human HPV16 E1/E4 fragment (amino acids 36-41) was used as the immunogen for this HPV16 E1/E4 antibody.
Storage: Store the HPV16 E1/E4 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
