Homogeneous SHP-2 Assay Kit (Catalytic Subunit) | 79317

Homogeneous SHP-2 Assay Kit (Catalytic Subunit) | 79317 | Gentaur US, UK & Europe Disrtribition

Category: Protein Phosphatase/Assay Kit

Application: Great for studying enzyme kinetics and HTS applications.

Background: Mammalian PTPases can be subdivided into 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. SHP-2 (PTPN11) is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.

Description: The Homogeneous SHP-2 Assay Kit is a complete assay system designed to measure SHP-2 activity for screening and profiling applications. Using this kit, only one simple step on a microtiter plate is needed to analyze the SHP-2 activity level. The fluorogenic substrate, DiFMUP, is incubated with purified SHP-2 and the enzymatic activity releases DiFMU fluorophore that can then be measured using a fluorescence reader.

Product Type: Assay Kit

Shippement Condition: -80°C