Description
HLA-DP + HLA-DQ + HLA-DR Antibody (MHC II) | V3374-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: CR3/43
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: ELISA, FACS, IF, WB, IHC-P
Buffer: N/A
Limitation: This HLA-DP/DQ/DR antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: This mAb reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some auto-immune diseases are associated with certain class II alleles.
Immunogen: Human tonsil cells were used as the immunogen for the HLA-DP/DQ/DR antibody.
Storage: Store the HLA-DP/DQ/DR antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
