HLA-DM Antibody (beta chain) | R30885

HLA-DM Antibody (beta chain) | R30885 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC-P

Buffer: N/A

Limitation: This HLA-DM antibody is available for research use only.

Purity: Antigen affinity

Description: Major histocompatibility complex, class II, DM beta, also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is encoded by the HLADMB gene. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chains, both anchored in the membrane. It is located in intracellular vesicles. The protein plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation.

Immunogen: An amino acid sequence from the middle region of human HLA-DM beta chain (NQKDTLMQRLRNGLQNCATH) was used as the immunogen for this HLA-DM antibody.

Storage: After reconstitution, the HLA-DM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.