HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag | GP1-H51H3-500ug
- SKU:
- 716-GP1-H51H3-500ug
- Availability:
- IN STOCK
- Size:
- 500 ug
Description
HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag | GP1-H51H3-500ug| Gentaur Distribution US, UK & Europe
Infection by HIV-1 involves the fusion of viral and cellular membranes with subsequent transfer of viral genetic material into the cell. The HIV-1 envelope glycoprotein that mediates fusion consists of the surface subunit gp120 and the transmembrane subunit gp41. gp120 directs virion attachment to the cell-surface receptors, and gp41 then promotes viral-cell membrane fusion. A soluble, alpha-helical, trimeric complex within gp41 composed of N-terminal and C-terminal extraviral segments has been proposed to represent the core of th e fusion-active conformation of the HIV-1 envelope. Three N-terminal helices within the bundle form a central, parallel, trimeric coiled coil, whereas three C-terminal helices pack in the reverse direction into three hydrophobic grooves on the surface of the N-terminal trimer. This thermostable subdomain displays the salient features of the core structure of the isolated gp41 subunit and thus provides a possible target for therapeutics designed selectively to block HIV-1 entry.
Source: HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag (GP1-H51H3) is expressed from E. coli cells. It contains AA Ala 533 - Leu 856 (Accession # P04578).
Format: Powder.
Tag: C-10×His.
Expression System: E. coli.
Expression Region: Ala 533 - Leu 856.
Conjugate: Unconjugated.
Molecular Weight: 44.3 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.3 kDa. The protein migrates as 42-44 kDa and 70 kDa under reducing (R) condition (SDS-PAGE).
Purity: 90%.
Buffer: 50 mM HEPES, 150 mM NaCl, 0.05% DDM, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT