Histone H2AX Antibody / H2AFX | F54477-0.2ML

Histone H2AX Antibody / H2AFX | F54477-0.2ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: 938CT5.1.1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P, WB

Buffer: N/A

Limitation: This Histone H2AX antibody is available for research use only.

Purity: Protein G affinity

Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Immunogen: A portion of amino acids 115-143 from the human protein was used as the immunogen for the Histone H2AX antibody.

Storage: Aliquot the Histone H2AX antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.