Description
HIPPI Antibody | F54213-0.05ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This HIPPI antibody is available for research use only.
Purity: Peptide affinity purified
Description: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Immunogen: A portion of amino acids 159-193 from the human protein was used as the immunogen for the HIPPI antibody.
Storage: Aliquot the HIPPI antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
