Description
HIPK1, GST-tag | 40179 | Gentaur US, UK & Europe Disrtribition
Category: Kinase-Serine/Threonine/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: HIPK1 or homeodomain-interacting protein kinase 1 is a ser/thr protein kinase and a member of the HIPK family. HIPK 1 is a nuclear kinase that phosphorylates homeodomain transcription factors. HIPK1 phosphorylates DAXX and this leads to its relocalization and subsequent decrease in transcriptional repression activity (1). HIPK1also interacts with p53 and phosphorylates it on serine residues. HIPK 1 expression is elevated in breast cancer cell lines and embryonic fibroblasts from HIPK 1-null mice show more susceptibility to apoptosis induced by DNA damage (2).
Description: Human HIPK1 (homeodomain-interacting protein kinase 1), also known as Myak and Nbak2 (GenBank Accession No. NM_152696), a.a. 156-555 with N-terminal GST tag, MW = 71 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
Product Type: Protein
Shippement Condition: -80°C
