Description
HES1 Antibody | F53422-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Mouse
Application: WB, ELISA
Buffer: N/A
Limitation: This HES1 antibody is available for research use only.
Purity: Antigen affinity
Description: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Immunogen: This HES1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 203-236 amino acids from the C-terminal region of human HES1.
Storage: Aliquot the HES1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
