Hepatocyte Growth Factor Antibody (HGF) | F40371-0.08ML

Hepatocyte Growth Factor Antibody (HGF) | F40371-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: 489CT6.12.6

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This HGF antibody is available for research use only.

Purity: Purified

Description: Hepatocyte Growth Factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 64-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq].

Immunogen: A portion of amino acids 521-554 from the human protein was used as the immunogen for this HGF antibody.

Storage: Aliquot the HGF antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.