Description
HEK293/Human APP (GFP) Stable Cell Line | CHEK-ATP081-2Vials| Gentaur Distribution US, UK & Europe
Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.
Species: Human.
Molecule: APP.
Tag: GFP Tag.
Format: Liquid.
Application: Screening β-secretase and γ-secretase inhibitors which stops Aβ peptide formation.
Storage Conditions: Frozen in liquid nitrogen.
Shipping Conditions: Dry ice
