GSK3 beta Monoclonal Antibody | E-AB-22220

GSK3 beta Monoclonal Antibody | E-AB-22220 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Application: WB, IHC-p

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Stem Cells

Background: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic Peptide of GSK3β

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification: Protein A purification

Dilution: WB 1:1000-2000, IHC 1:100-200

Conjugation: Unconjugated

Calculated Molecular Weight: N/A

Observed Molecular Weight: 46 kDa

Clonality: Monoclonal