GSK3 beta Antibody / GSK3B | F54007-0.1ML

GSK3 beta Antibody / GSK3B | F54007-0.1ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 50% Glycerol and 0.03% ProClin 300

Format: Purified

Clone: 2E6-D6-C12

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse, Rat

Application: WB, ICC/IF, IP

Buffer: N/A

Limitation: This GSK3B antibody is available for research use only.

Purity: Protein G affinity

Description: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. [UniProt]

Immunogen: A recombinant partial protein was used as the immunogen for this GSK3B antibody.

Storage: Store the GSK3B antibody at -20 °C.