Description
GRPR Polyclonal Antibody | E-AB-12444 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Application: WB, IHC, ELISA
Research Area: Cancer, Neuroscience, Signal Transduction
Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Lead Time: 7~10 days
Concentration: 1.1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human GRPR
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification: Affinity purification
Dilution: WB 1:200-1:1000, IHC 1:50-1:200
Conjugation: Unconjugated
Calculated Molecular Weight: 43 kDa
Observed Molecular Weight: N/A
Clonality: Polyclonal
