Description
GRP78 Antibody / BiP / HSPA5 | F54266-0.05ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: WB, IHC-P, IF, FACS
Buffer: N/A
Limitation: This HSPA5 antibody is available for research use only.
Purity: SAS precipitation
Description: In cooperation with other chaperones, HSP70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. The HSP70s in mitochondria and the endoplasmic reticulum play an additional role by providing a driving force for protein translocation. They are involved in signal transduction pathways in cooperation with HSP90. They participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
Immunogen: Full length recombinant human protein was used as the immunogen for the HSPA5 Antibody.
Storage: Aliquot the HSPA5 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
