Description
GRB2 Antibody | F49558-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC, ELISA
Buffer: N/A
Limitation: This GRB2 antibody is available for research use only.
Purity: Purified
Description: GRB2 is an adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. [UniProt]
Immunogen: A portion of amino acids 89-118 from the human protein was used as the immunogen for this GRB2 antibody.
Storage: Store at 4oC for up to one month. For long term, aliquot the GRB2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
