Description
GPC3 Lentivirus | 78711 | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Lentivirus
Application: Generate stable cell line expressing human GPC3 with puromycin selection
Background: GPC3 (Glypican-3, also known as OCI5) is a cell surface proteoglycan highly expressed in the lungs, liver, and kidneys. Its function is tissue-dependent and can either promote or suppress tumorigenesis. Being a heparin sulfate proteoglycan, it is overexpressed in neoplasms including malignant melanoma, hepatocellular carcinoma, and testicular yolk sac tumors in which it regulates cell growth and differentiation. It is also involved in the negative regulation of the hedgehog signaling pathway and in the positive regulation of the non-canonical Wnt signaling pathway.
Description: The GPC3 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human GPC3 (Glypican 3, NM_ 004484.2) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the GPC3 Lentivirus.
Product Type: Lentivirus
Shippement Condition: -80°C
