Glycoprotein 2 Antibody / GP2 / ZAP75 | V7816SAF-100UG

Glycoprotein 2 Antibody / GP2 / ZAP75 | V7816SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: GP2/3416

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, IHC-P

Buffer: N/A

Limitation: This Glycoprotein 2 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Immunogen: A recombinant human partial protein (amino acids 35-179) was used as the immunogen for this Glycoprotein 2 antibody.

Storage: Store the Glycoprotein 2 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).