Glycophorin A (CD235a) CHO Cell Line | 78353

Glycophorin A (CD235a) CHO Cell Line | 78353 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: Development and optimization of Glycophorin A-binding antibodies or related peptides; Assay Development

Background: Glycophorin A (GYPA, also known as CD235a) is a sialoglycoprotein and a major intrinsic membrane protein on the surface of human erythrocytes. GYPA plays an important role in the prevention of red cell aggregation in the circulatory system. The Glycophorin A gene contains some antigenic alleles of the MNS blood grouping system for which 40 known variants exist. Several of these antigenic variants have implications for pathogen interaction.  For example, the Wright b antigen in the helical region of Glycophorin A acts as a receptor for the malaria parasite Plasmodium falciparum. Other variations such as the Mur phenotype causes hemolytic transfusion reaction (HTR) and hemolytic disease in the newborn fetus (HDFN). Glycophorin A is one of the most abundant integral proteins of the red cell membrane, and its genetic sequence varies within a population; therefore, it may also support applications in forensic science.

Description: Recombinant clonal CHO-K1 stable cell line constitutively expressing full-length human Glycophorin A (GYPA, transcript variant 1, Seq ID: NM_002099.8). The surface expression of Glycophorin A was validated by flow cytometry.

Product Type: Cell Line

Shippement Condition: -80°C