Glutamine Synthetase Antibody / GLUL | V8915-20UG

Glutamine Synthetase Antibody / GLUL | V8915-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: GLUL/6600

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, IHC-P

Buffer: N/A

Limitation: This Glutamine Synthetase antibody is available for research use only.

Purity: Protein A/G affinity

Description: Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

Immunogen: A portion of amino acids 50-250 was used as the immunogen for the Glutamine Synthetase antibody.

Storage: Aliquot the Glutamine Synthetase antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.