Description
GITR / Tnfrsf18 (Mouse)(DTA-1), CF647 conjugate, 0.1mg/mL Antibody | BNC470976-100| Gentaur Distribution US, UK & Europe
Summary.: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response..
Conjugate: CF647.
Storage Buffer: PBS, 0.1% BSA, 0.05% azide.
Storage Temperature: 2°C to 8°C.
Application: Flow, surface (published)|Functional studies (published).
Stability: Stable at room temperature or 37°C (98°F) for 7 days.
