Description
GITR Antibody / TNFRSF18 | V3050-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: DTA-1
Host Animal: Rat
Clonality: Monoclonal (rat origin)
Species Reactivity: Mouse
Application: FACS, IF
Buffer: N/A
Limitation: This GITR antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Immunogen: Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody.
Storage: Store the GITR antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
