GDF15 [Biotinylated]: GFRAL Inhibitor Screening ELISA Kit | EP-164-96tests

GDF15 [Biotinylated]: GFRAL Inhibitor Screening ELISA Kit | EP-164| Gentaur Distribution US, UK & Europe

Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1) . Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS) . It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.

Source: Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1) . Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS) . It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.

Molecule: GDF15.

Format: Solid.

Species: Human.

Application: This kit is developed for screening for inhibitors of human GDF-15 binding to human GFR alpha-like.

Kit Component: This inhibitor screening ELISA kit is designed to facilitate the identification and characterization of new OX40 pathway inhibitors. The assay takes advantage of our in house-developed binding of biotinylated human OX40 to immobilized human OX40 Ligand in a functional ELISA assay, and employs a simple colorimetric ELISA platform. Briefly, we provide you with a human Biotinylated OX40 protein, a human OX40 Ligand protein, an anti-OX40 neutralizing antibody (as method verified Std.), and Streptavidin-HRP reagent.

Stability: The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 64 days from the date of opening.

Storage Conditions: 2-8℃.

Shipping Conditions: Blue ice