GCK Polyclonal Antibody | E-AB-40270

GCK Polyclonal Antibody | E-AB-40270 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Application: WB, IHC, IF

Research Area: Cancer, Metabolism, Signal Transduction

Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Mouse Glucokinase protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification: Antigen Affinity Purification

Dilution: WB 1:1000-1:2000 IHC 1:100-1:200 IF 1:100-1:400

Conjugation: Unconjugated

Calculated Molecular Weight: 52 kDa

Observed Molecular Weight: 52 kDa

Clonality: Polyclonal