Description
GATA3 Antibody | V9369-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: GATA3/4550R
Host: Rabbit
Clonality: Recombinant Rabbit Monoclonal
Isotype: Rabbit IgG, kappa
Species Reactivity: Human, Rat
Application: IHC-P, WB
Application Details: Immunohistochemistry (FFPE): 1-2ug/ml,Western blot: 1-2ug/ml
Application Note: Optimal dilution of the recombinant GATA3 antibody should be determined by the researcher.
Purity: Protein A/G affinity
Description: GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50kDa nuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas, but none of prostate or renal carcinomas.
Immunogen: A conserved peptide between the GATA trans-activation and DNA-binding domain was used as the immunogen for the recombinant GATA3 antibody.
Storage: Aliquot the recombinant GATA3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
Localization: Nuclear
