Description
Gamma Catenin Antibody / Plakoglobin | V3205-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: 15F11
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Mouse, Rat
Application: FACS, IF, WB, IHC-P
Buffer: N/A
Limitation: This Plakoglobin antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt]
Immunogen: Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody.
Storage: Store the Plakoglobin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
