Gamma Catenin Antibody / Plakoglobin | V3204-100UG

Gamma Catenin Antibody / Plakoglobin | V3204-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: 11E4.

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse

Application: IF, WB, FACS

Buffer: N/A

Limitation: This Plakoglobin antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: It recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (α, β, γ and δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. α T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. α T-catenin binds to α E-catenin as well as to β-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for α-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Immunogen: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Storage: Store the Plakoglobin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).