GAD1 Polyclonal Antibody | E-AB-17390

GAD1 Polyclonal Antibody | E-AB-17390 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Application: WB, IHC, ELISA

Research Area: Cancer, Metabolism, Immunology, Signal transduction

Background: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Lead Time: 7~10 days

Concentration: 0.2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human GAD1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification: Affinity purification

Dilution: WB 1:200-1000, IHC 1:25-100, ELISA 1:1000-2000

Conjugation: Unconjugated

Calculated Molecular Weight: 67 kDa

Observed Molecular Weight: N/A

Clonality: Polyclonal