Description
FZR1 Antibody / Fizzy related protein 1 | F53804-0.05ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: 1621CT637.76.67
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This FZR1 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Fizzy related protein 1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Immunogen: Human recombinant protein corresponding to amino acids 1-496 was used as the immunogen for this FZR1 antibody.
Storage: Aliquot the FZR1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
