Description
Furin Antibody | R31596 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This Furin antibody is available for research use only.
Purity: Antigen affinity
Description: Furin (Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. Furin is thought to play a role in tumor progression. It is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression in T-cells is required for maintenance of peripheral immune tolerance.
Immunogen: Human partial recombinant protein (AA 591-794) was used as the immunogen for this Furin antibody.
Storage: After reconstitution, the Furin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
