Description
Frataxin Antibody / FXN | V3997SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: FDAX-1
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P, WB
Buffer: N/A
Limitation: This Frataxin antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Reduced expression of frataxin is the cause of Friedreich's ataxia (FRDA), a lethal neurodegenerative disease. The reduction in frataxin gene expression may be attributable from either the silencing of transcription of the frataxin gene because of epigenetic modifications in the chromosomal entity or from the inability of splicing the expanded GAA repeats in the first intron of the pre-mRNA as seen in bacteria and human cells or both. The expansion of intronic trinucleotide repeat GAA results in Friedreich's ataxia. [Wiki]
Immunogen: Amino acids 57-210 from the human protein were used as the immunogen for this Frataxin antibody.
Storage: Store the Frataxin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
