Frataxin Antibody / FXN | V3997IHC-7ML

Frataxin Antibody / FXN | V3997IHC-7ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

Format: Purified

Clone: FDAX-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This Frataxin antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Reduced expression of frataxin is the cause of Friedreich's ataxia (FRDA), a lethal neurodegenerative disease. The reduction in frataxin gene expression may be attributable from either the silencing of transcription of the frataxin gene because of epigenetic modifications in the chromosomal entity or from the inability of splicing the expanded GAA repeats in the first intron of the pre-mRNA as seen in bacteria and human cells or both. The expansion of intronic trinucleotide repeat GAA results in Friedreich's ataxia. [Wiki]

Immunogen: Amino acids 57-210 from the human protein were used as the immunogen for this Frataxin antibody.

Storage: Store the Frataxin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).