FOXP3 Antibody | F48211-0.08ML

FOXP3 Antibody | F48211-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, IHC, FACS, ELISA

Buffer: N/A

Limitation: This FOXP3 antibody is available for research use only.

Purity: Antigen affinity

Description: Forkhead box P3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). [UniProt]

Immunogen: A portion of amino acids 283-311 from the human protein was used as the immunogen for this FOXP3 antibody.

Storage: Store at 4oC for up to one month. For long term, aliquot the FOXP3 antibody and store frozen at -20 °C or colder.