Description
FOXO3A Antibody | R31609 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Rat
Application: WB, IHC-P
Buffer: N/A
Limitation: This FOXO3A antibody is available for research use only.
Purity: Antigen affinity
Description: Forkhead box O3, also known as FKHRL1 or FOXO3A, is a human protein encoded by the FOXO3 gene. FOXO3A belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. It is mapped to 6q21. This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim andPUMA, or downregulation of anti-apoptotic proteins such as FLIP. In mammals FOXO3A regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span. In addition, it is thought that FOXO3A is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.
Immunogen: Human partial recombinant protein (AA 471-673) was used as the immunogen for this FOXO3A antibody.
Storage: After reconstitution, the FOXO3A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
