FLT3 Polyclonal Antibody | E-AB-40475

FLT3 Polyclonal Antibody | E-AB-40475 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Application: WB, IHC

Research Area: Immunology, Signal Transduction

Background: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Lead Time: 7~10 days

Concentration: 1mg/mL

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Immunogen: Recombinant Mouse Receptor-type tyrosine-protein kinase FLT3 protein

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.

Purification: Antigen Affinity Purification

Dilution: WB 1:1000-1:3000 IHC 1:100-1:300

Conjugation: Unconjugated

Calculated Molecular Weight: 113 kDa

Observed Molecular Weight: 113 kDa

Clonality: Polyclonal