Description
FITC Anti-Mouse IL-17A Antibody | DL22162F-2 | Gentaur US, UK & Europe Disrtribition
Synonyms: Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8
Reactivity: Mouse
Host: Rat
Application: ICFCM
Background: IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
Concentration: 0.5 mg/mL
Conjugation: FITC
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Rat IgG1, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
